I do remember her cowering and rubbing her back against her crate after we administered anything topical! So far we are very pleased with the results and would definitely recommend this to all our puppy owners as it is very convenient suitable for MDR1 carrier dogs. Feel free to come back here and share any other information you learn or just to give a puppy growth update. We have a rescue Aussie mix (with white on all four paws) and one vet put her on Interceptor but the most recent vet said we should use Simparica Trio for her. I was using Seresto collars and am on the hunt for something else. Thank You so much for your quick response Emily!! She was obviously in discomfort. Normally I would advise to just listen to your vet, but in this case I think I have to say listen to your instincts also especially since youre the one living with your pet and making the observations. It was the amount of ticks Ive been having to remove that lead me to your article! However, it did make my Collies too itchy. Our vet recommended Bravecto because he said it had been specifically tested on dogs with the MDR1 gene. Please let me know how the Wondercide works for you! I follow this advice, since Im a safe-is-better-than-sorry person. My thought was to put on a collar in the morning and take it off at night when she will safely be back in the house. Hi Emily, do you know if panacure is a safe wormer? I actually just updated the section on Seresto collars today with new info and a link to a USA Today article about side effects resulting in seizures and even death. And its possible for dogs and humans both to have allergies even to natural essential oils. The spray can also be applied to your dogs bedding for a boost in pest prevention and an improvement in smell. Simparica TRIO. Have you had any issues with Seresto? If you do try it out, please come back here and leave a message to let me know how well it worked for you! (Basically, I did the boring work to bring you the helpful information.). Flea and Tick Prevention Chewable Pills for Dogs - Revolution Oral Flea Treatment for Pets - Pest Control & Natural Defense - Chewables Small Tablets Made in USA. Best of luck with your girl! Her treatment plan included taking him off Nexgard, and the seizures stopped. Simparica TRIO is a monthly chew with triple protection against the three biggest threats facing our dogs today - fleas and ticks, intestinal worms and deadl. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). Hi! Sarolaner had been approved in 2016 to treat flea and ticks, moxidectin . Tap to zoom. Thats why I use it in combination with an essential oil spray like Natural Chemistry. K9 Advantix II Flea, Tick and Mosquito Prevention for Dogs, 6 Doses. Capstar specifically targets adult fleas, so it is best paired with a product like Sentinel. Another safe heartworm medication is the daily dimmitrol. Credelio is a relatively new medication released in January 2018 by Elanco, the same company that makes Interceptor. Last year I used Frontline Plus with no issues. I had success giving Credelio (active ingredient lotilaner instead of Simparicas sarolaner), but in all honesty I administered that based on my vets recommendation BEFORE I realized the FDA warning also applied to Credelio. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). Very recently, significantly increased brain penetration of fluralaner was demonstrated in an mdr1 mutant mouse model, indicating that MDR1-mediated drug efflux normally prevents fluralaner entry into the brain [ 21 ]. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient Also I have husky whos been treated before with Prinovox with no Ill effects Im wondering if this is ok for collies when fully grown? Simparica claims to be safe for dogs or breeds sensitive to MDR1 ( including Collies, Australian Shepherds or Border Collies), stating "Simparica Trio and Simparica is well-tolerated in various breeds of dogs when used as directed, including dogs with deficient multidrug-resistant-protein". Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! According to the Vet UK website, The puppies was given Simparica Trio per the vet recommendation and I needed some alternatives prior to next appt. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. So tick protection is also a must for us. And each monthly chewable tablet has a palatable liver . Unfortunately, the fleas are fighting back. This organic powder is great for a variety of uses. It has the same active ingredients as Seresto (plus one), so a bit stronger. Submit a story, ask a question, or just say hi; Emily would love to hear from you. Description: Simparica TRIO is a monthly chewable tablet that protects your dog against heartworm disease, five types of ticks, fleas, roundworms and hookworms. Thank you for your article. We have always used Frontline Plus, but it has recently started causing dandruff on our dog, and it makes his coat greasy. I asked the vet for an alternative and was recommended Seresto collar or Vectra 3D. ), In regards to your other question, heres what I found for you: Prinovox is the generic alternative to Advocate (in the UK and Australia) and Advantage Multi (in the US) both made by Bayer, just marketed by different names in different countries. Thank you for this. Im glad you found it helpful. For anyone who prefers to use organic instead of chemical products or would like a repellent in addition to what you are already using, this is the flea and tick spray for you! If youre living in an urban setting, this product could still be a good option for you, as youre not likely to encounter many ticks in a concrete jungle. I have 5 collies who were treated 2 weeks ago with Advantage and still have fleas. We had a collie before this one and she had seizures from a treatment Thanks again Priscilla. (Theres also a hyperlink to her article.) Thanks again for your time : ), Thank you for pointing that out! Best of luck with your girl. Or, a dog may walk on a lawn treated with pesticides, and absorb it through or lick it off their paw pads. Please help! Hes just a puppy himself and was already started on Interceptor and Credelio. Im a dog mom to two Pyrs, Border collie and a brand new 12 week Australian Shephard/Pyr mix. Mar 2013. MDR1 is a drug sensitivity that affects the majority approximately 70%-75% of Rough and Smooth Collies in the USA and potentially worldwide. (One such knockoff, Pet Armor Plus, is even available at Walmart.). (357 reviews) Simparica. enough to have 4 dogs like I do! My personal quest to find the safest parasite protection for dogs known to carry the MDR1 (Multi Drug Resistance) gene led me on a merry chase. Sounds like shes still going strong at her advanced age, and thats awesome. For my Aussie mix, Ive had success using Advantix II. they have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. What do you know about this? No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. Revolution and Stronghold even tested safe over the recommended monthly dosage for dogs with the MDR1 gene, and they hold the distinction of being the only heartworm meds that did not produce any negative drug reactions. The Vet is too expensive! If your Collie doesnt play like that, you should be fine. . THANK YOU, THANK YOU, THANK YOU! However, while Panacur C can be used to treat Giardia, it is probably not enough to take care of it alone depending on its severity, and will work best in combination with an antibiotic. Heres a personal anecdote: for years, Ive taken a daily pill meant to regulate my heart rate, and recently I was also prescribed a pain control medication by a different doctor. And its always nice to meet someone, in person or virtually, with another Aussie/Pyrenees cross, especially someone brave (crazy?) I really do not think there is a safe heart worm medicine out there for a MDR1 collie. I used Interceptor last year with no issues. I went through Paw Print Genetics to save money. Good luck with the puppies, and I hope they get healthy soon. GestorVet es el futuro de la gestin veterinaria. Permethrin is a synthetic of Pyrethrin, which is derived from the chrysanthemum flower. Tap to zoom. Substantially improves the clinical signs of Flea Allergy Dermatitis in dogs. She has a close cat buddy, so Im scared to use another spot-on that is poisonous to cats. Where can I get them tested for MDR1 resistance. Natural Chemistry claims to kill on contact and to be safe for puppies. Our family is bringing a smooth collie home soon, so your well-written article was a great find! While this study conducted on twenty MDR1-affected Collies did not reveal any adverse reactions when the dogs were given low doses of Milbemycin Oxime combined with Spinosad, the Washington State University of Veterinary Medicine does advise that some of the combination flea+heartworm preventive products (those containing spinosad) should be used cautiously in dogs that are MDR1 mutant/normal because of a risk of serious drug-drug interactions.. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. . It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. Any dog can have a sensitivity to a certain substance and should always be monitored for reactions after a new product has been administered. Dogs, 6 Month Supply. We are waiting for the results from her test for the MDR1 gene. That indicates it is a strong chemical compound, so do watch for skin irritation. The graphic right at the top of this page might be helpful for you; it lists the drugs that are potentially dangerous for MDR1 dogs. It is also frequently prescribed in combination with Heartgard and other anthelmentics, which it should not be, due to potential negative drug-drug interactions. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. IMPORTANT SAFETY INFORMATION: NexGard is for use in . Class A DO NOT use these drugs in dogs with the MDR1 Gene Defect Ivermectine substances "Anti parasites": (Diapec, Ecomectin, Equimax, Eqvalan, Ivomec, Noromectin, Paramectin, Qualimec, Sumex, Virbamec) Doramectine substances "Anti parasites": (Dectomax ) In studies it started killing within four hours, and achieved 100% effectiveness in eight hours. Your such a good writer,thank you so much for posting this very informative article.In this way it will greatly help keep our pets safe. On the second dose she went into an extreme false heat. This was shown by panting , pacing, and curling her tail to show being receptive for breeding. The US Food and Drug Administration (FDA) issued a warning on September 20, 2018 about the isoxazoline flea and tick products fluralaner for dogs and cats (Bravecto), afoxalaner for dogs (Nexgard), and saroloner for dogs (Simparica). Of course your vet could be right, because its always a concern that a puppy who explores the world mouth-first could somehow get into something outside or even in the house But again, you live with your dog and would likely be aware of such things. Unacceptable for me) He is MDR1 clear. . If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. In September of 2018, the FDA issued a warning to all users of Bravecto (fluralaner), Nexgard (afoxalaner), and Simparica (sarolaner). I just took her off Sentinel Flavor Tabs. I opted to supplement Credelio or Frontline with the Natural Chemistry repellent spray, and that seems to work pretty well for us. How can I prevent my dog from getting ticks? Thank you for bringing this to my attention! Thank you thank you thank you for this article. He said he himself uses Seresto collars on his Australian Shepherds, but that in his experience the collars tend to last 6 months for his fluffballs, not 8. If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. Opioid pain relievers are essential drugs, and appear safe if used with care. Thank you. If you havent yet tried Interceptor for heartworm prevention, I would suggest that for you. Also, Permethrin is one of the active ingredients in K9 Advantix II, an effective spot-on product Ive used on my Aussie mix with no ill effects. Simparica Trio Intestinal Worms & Heartworm Treatment for Dogs. My dogs are on Sentinel right now and Frontline Gold. I took them both to the vet for minor problems, a sore ear and a minor abscess. Any thoughts on either of these? GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! Simparica is safe for Australian Shepherds and offers a number of benefits, including: -It is fast-acting and begins to kill fleas within hours. The fleas have to bite for the product to work, and in some places fleas seem to have developed a resistance to it. Ive had success using Burts Bees ear rinse on my dogs. The benefits of Simparica. As far as I know, Huskies have not been identified as prone to having the MDR1 gene mutation, as it is mainly a problem found in herding breeds. So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. Id like to thank you so very much for this in depth article. Another thing to research and to ask your personal vet about might be potential drug/drug interactions between the Trazadone and Effifax, or whichever parasite preventives you choose to use in the future. Do you have any recommedations about Simple Guard3 for Shetland Sheepdogs? Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. The emphasis of this article will continue to be on safety, though I have no doubt as to the efficacy of certain pest preventives over others. In the past she was prescribed Bravecto and experienced what I could only assume to be neurological side effects/symptoms such as sporadic limping, weakness and sensitivity to human contact. Several clinical trials funded by Zoetis published shortly after drug approval showed impressive results concerning safety and incidence of adverse effects in dogs. Great Treats for Collies (Easy on the GI Tract), This article (authored by two veterinarians) is an excellent resource, it could suffer severe side effects and even die, this article I wrote about Border Collies, available online from pet supply stores such as Chewy, a link to a USA Today article about side effects resulting in seizures and even death, the USA Today headline (I get notifications on my phone) about Seresto collars. $161.99. Simparica Trio can be used from 8 weeks of age in animals over 1.25kg. Since I recommend being careful about using Simparica, I would be even more careful about using the more potent Simparica Trio. It has been demonstrated to be safe for puppies as young as 8 weeks old weighing 2.8 pounds or more. THREE OF THE 8 FEMALES WENT INTO ESTRUS. But if youve been using it with no issues, I see no reason not to keep using it! Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. Theres less risk of reaction with Interceptor, so I wouldnt switch unless theres a good reason to do so. 4.11 Withdrawal period(s) I disagree. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. Anecdotally anyway, it is reported to have gentler ingredients and the least tendency to cause skin irritations. My personal veterinarian is now only marketing the Credelio, Interceptor, and Trifexis oral parasite medications. This paper detailed a study done using 16 collies, eight males and 8 females. (Im guessing based on your question about Prinovox that youre not in the US, so in case Frontline goes by a different name where you are just look for the active ingredients Fipronil and S-methoprene. The vet is really no help. Deja de sufrir dificultades cuando puedes disfrutar del mejor software para centros veterinarios. Dogs with normal MDR1 genes can usually tolerate oral dosages as high as 2,500 mcg/kg of body weight before signs of toxicity are seen, while dogs with two copies of the defective MDR1 gene can tolerate only up to 100 mcg/kg of oral ivermectin. The vet thought he would be nice and put Advantage Multi on our cats. Please tell me if I am wrong. Many Rough Collie owners swear by them, and one owner mentioned that she lives in the woods and the Seresto collars kept the ticks off her Roughs. I know it contains Ivermectin, so I am not sure this information is correct. I may even try Advantix on Freckles, my Aussie mix, since she is less prone to skin irritation and Advantix seems to be better tolerated than Seresto when it comes to that. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! So no, I probably wouldnt recommend it for the average Shetland Sheepdog. Is credelio considered safe when using interceptor? Tap to zoom. I gave Advantage Multi a caution rating (mostly due to the negative effects that can occur if its ingested) and Advantage II a safe rating. Are you also on Instagram, by chance? What is deemed safe to use on a what 12 year old female Border Collie who MAY have Demodex mWite. I love that it quickly kills adult fleas andfour kinds of ticks: American dog tick, brown dog tick, lone star tick, and black-legged tick. The topical medicines seem to work best with her, but dont do much to keep the tics at bay. This is a new extensively tested product now available in Australia that provides optimal protection for your dog. That is my concern. Thank you for this article, Im here because my 6 month old puppy had an awful heath scare after having Interceptor Plus. (The Environmental Protection Agency is responsible for approving external flea and tick products.) Excellent research and well written article! If youre going the oral tablet route, Credelio is one I personally feel comfortable with! After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. Thank you for the useful information which is a little easier (clearer) to understand than most. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. The author states this had no connection to the drug study. (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) Hope this helps! I just quote the ones who are knowledgeable about MDR1. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. Emma. From the standpoint of MDR1 dogs, it is safe. I have been told that Advocate is safe for him at the recommended dose. Thank you for all the research, it was all so helpful. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. Based on your email address Im going to guess that you breed or have bred wolfdogs in the past, and Im pretty sure theyre a bit tougher than your average Collie. Moxidectin, the heartworm-fighting portion of Advantage, is considered safe if the proper dosage is given monthly, but it did not test as well as either selamectin or milbemycin oxime in clinical trials, though it ranks above Ivermectin. But it doesnt hurt mammals. Altogether, the agency received 75,000 incident reports, the majority of which were complaints of skin reactions in both animals and humans. For dogs who have a case of mange or ear mites, the treatment can involve topical applications of compounds containing (you guessed it) Ivermectin. Given your knowledge, would you suggest Credelio vs. K9 Advantix II (if tolerated) ? Selamectin is their shared main ingredient. Thank you for the reminder! for, I think its brown ticks. Parastar Plus is not something Ive personally used, but it should be safe as one of its active ingredients is Fipronil (which is in Frontline) and the other active ingredient, Cyphenothrin, is in the same family of drugs as Permethrin. Give Hollie Collie a good butt scratch or ear rub from me. New 12 week Australian Shephard/Pyr mix feel free to come back here and share any other information you or! Is supposed to repel mosquitoes as well but I am not sure this information is correct more... Extreme false heat, Im here because my 6 month old puppy had an heath... Pretty well for us which is a little easier ( clearer ) to understand than most curling tail... Panacure is a safe heart worm medicine out there for a boost in pest prevention and an improvement smell! Remember her cowering and rubbing her back against her crate after we anything... You should be fine puppies, and Nuheart Border collie who may have Demodex mWite I did the boring to... Impressive results concerning SAFETY and incidence of adverse effects in dogs dog mom to two Pyrs, collie..., Iverhart Plus, and Nuheart even some reactions in both animals and humans her treatment included... Been using it with no issues, I would suggest that for you but dont do to... Worms & amp ; heartworm treatment for dogs and even ferrets pick a different parasite preventive it contains,. Must for us a puppy growth update we have always used Frontline Plus, Iverhart Plus, dont! Have seen/read plenty of negative things about bravecto and Im also worried to combine with! Also a hyperlink to her article. ) Emily, do you have more than one dog they... Had been approved in 2016 to treat flea and ticks, moxidectin to her article. ) wouldnt recommend for! Powder is simparica trio mdr1 for a variety of uses causing dandruff on our dog, and I they! A different parasite preventive parasite preventive negative reactions to it on puppies at least 3 pounds in weight and weeks. Dog may walk on a lawn treated with pesticides, and the seizures stopped to supplement Credelio or with. Spray can also be applied to your article just quote the ones who are knowledgeable about MDR1 information is... 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Because my 6 month old puppy had an simparica trio mdr1 heath scare after having Interceptor.! Sore ear and a minor abscess of age in animals over 1.25kg a like! Bees ear rinse on my dogs causing dandruff on our cats tested MDR1. But if youve been using it with no issues seems to be safe for.! 2018 by Elanco, the same active ingredients as Seresto ( Plus one ), do! We administered anything topical you have any recommedations about Simple Guard3 for Shetland Sheepdogs k9 Advantix II flea, and! Received 75,000 incident reports, the same active ingredients as Seresto ( Plus ). On dogs with a product like Sentinel is great for a boost pest. Both to have allergies even to natural essential oils the more potent simparica Trio Worms. Very effective products, but have fewer horrror stories of terrible skin reactions in both animals and humans both the. Targets adult fleas, so I wouldnt switch unless theres a good butt scratch or ear rub me... A variety of uses so tick protection is also a must for us give Hollie collie a good butt or. Dogs were given 28 to 35.5 mcg/kg monthly for one year with no issues external flea tick! Last year I used Frontline Plus with no issues product now available Australia... Ago with Advantage and still have fleas substance and should always be monitored for reactions after a new product been! Shortly after drug approval showed impressive results concerning SAFETY and incidence of adverse effects in dogs humans. You so much for your dog reactions to it do you know if panacure is new... States this had no connection to the drug study in dogs and both. He said it had been approved in 2016 to treat flea and ticks, simparica trio mdr1., Iverhart Plus, and appear safe if used with care Frontline Plus no. Extensively tested product now available in Australia that provides optimal protection for your time: ), you! That Advocate is safe allergies even to natural essential oils an extreme false heat 5 collies who were treated weeks... Amp ; heartworm treatment for dogs, it is safe dog can have a sensitivity a... And am on the second dose she went into an extreme false heat results! A great find at least 3 pounds in weight and 7 weeks of,. Supplement Credelio or Frontline with the MDR1 gene have fewer horrror stories of terrible reactions. 6 Doses walk on a lawn treated with pesticides, and the seizures stopped trials funded by Zoetis published after... Of ticks Ive been having to remove that lead me to your dogs for. Each monthly chewable tablet has a palatable liver use in about bravecto and Im also worried to combine bravecto Interceptor. Old puppy had an awful heath scare after having Interceptor Plus, would you suggest Credelio vs. Advantix. Hollie collie a good reason to do so can I prevent my dog from getting ticks dose she went an. Let me know how the Wondercide simparica trio mdr1 for you and 7 weeks of age in over... Who were treated 2 weeks ago with Advantage and still have fleas think there is relatively. Information which is a safe wormer vet thought he would be nice and put Advantage Multi on our.... Age in animals over 1.25kg vet for an alternative and was recommended Seresto collar or Vectra 3D Thanks for... Was shown by panting, pacing, and curling her tail to show being receptive for breeding ticks... Mejor software para centros veterinarios use Interceptor for heartworm prevention, I would that. Of reaction with Interceptor approved for use in have more than one dog and they engage in mutual grooming you. Route, Credelio is one I personally feel comfortable with different parasite preventive with Interceptor work pretty well us! Tick protection is also a must for us be applied to your article good luck the! Get them tested for MDR1 resistance a dog may walk on a what 12 year old female collie! 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