We are very happy that he decided to form a company focused on leading-edge technologies with transformative potential, assembled a great team of seasoned drug hunters and chose to collaborate with us, on both target discovery and generative chemistry," said Alex Zhavoronkov, PhD, CEO of Insilico Medicine. Cancer Lett. 2012 Oct;11(10):2149-57. doi: 10.1158/1535-7163.MCT-12-0195. He touches on OPUS-X and AlphaFold and how each contribution has advanced our capability and understanding. 2016 Oct 1;380(2):494-504. doi: 10.1016/j.canlet.2016.07.021. Design Therapeutics. Strategies to overcome acquired resistance to EGFR TKI in the treatment of non-small cell lung cancer. National Library of Medicine Together, we continue to lead the development and dissemination of optimal methods and practices in clinical trials, while . Significance: In this role, Dr. Ding identified, fostered the growth of, and collaborated with multiple innovative biotechnology companies. Linkedin. Close Appointment form contact@ai-biopharma.com Categories Home Company Services Pipeline News & Events Contact AllianThera Biopharma lead by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases. Cancer Discov 2020;10:2639. A, PEM treatment co-opts cGAS-STING signaling, PEM treatment co-opts cGAS-STING signaling in MET-amplified EGFR-TKIresistant cells. "Most of the pharmaceutical and biotechnology companies these days are working more or less on similar well-known targets and the innovation is in new molecular structures. The company focuses on discovery and development of translational medicine in metabolic and immune-related diseases. Win whats next. All content is posted anonymously by employees working at AllianThera Biopharma. Advanced Search Title. Unable to load your collection due to an error, Unable to load your delegates due to an error. We are very happy to collaborate with Insilico Medicine which has unique capabilities in target discovery and generative chemistry", said Yuan-Hua Ding, PhD, Co-founder and CEO of ATB. Founded in 2020. In this lecture, Dr. Levitt describes how the work he began over 50 years ago has been vastly improved and expanded through the massive increase in computer speed and incredible advances in machine learning. The companies utilized a pipeline of Insilico Medicine's artificial intelligence platforms including PandaOmics to identify a list of promising targets in cancer and autoimmune diseases and prioritize novel high-confidence targets to progress into early-stage drug discovery. In this role, Dr. Ding identified, fostered the growth of, and collaborated with multiple innovative biotechnology companies. The Registered Agent on file for this company is CT Corporation System and is located at 155 Federal St., Ste. Co-Founder & CEO at ATB (AllianThera Biopharma) Southborough, Massachusetts, United States 3K followers 500+ connections Join to view profile ATB (AllianThera Biopharma) University of. Federal government websites often end in .gov or .mil. In an allogenic humanized mouse model, CD73 deletion enhanced immunogenicity of MET-amplified, EGFR-TKI-resistant cells, and PEM treatment promoted robust responses regardless of CD73 status. These data reveal that combined PEM and CD73 inhibition can co-opt tumor cell STING induction in TKI-resistant EGFR-mutated lung cancers and promote immunogenicity. Accessibility . Clin Cancer Res 2018;24:6195203. China. Description. A, Tumor volume of HCC827GR6 cells with, MeSH -, Nagano T, Tachihara M, Nishimura Y. Founder of Allianthera Biopharma Co. and New England Structural Biology Association, Inc., Yuan Hua Ding occupies the position of Chief Executive Officer for Allianthera Biopharma Co. and Chief. Bookshelf As a pharmaceutical company with global vision, supported by the domestic and foreign famous funds, Alpha Biopharma is committed to the clinical development of global innovator drug. * We use standard office opening hours in near AllianThera Biopharma's location as default value for unknown and outdated data. AllianThera Biopharma Updated February 18, 2023 Popular Jobs on Glassdoor Mechanical Engineer Jobs IT Jobs Human Resource Jobs Healthcare Jobs Graphic Designer Jobs Account Executive Jobs Registered Nurse Jobs Pharmaceutical Sales Jobs Guide to Getting Your First Job Find a Great First Job to Jumpstart Your Career How to Get a Job For more valid info, please verify the info from more trusted sources like GoogleMyBusiness, Yelp, FourSquare or similar services. AllianThera Biopharma led by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases. Polly Firs official website and that any information you provide is encrypted Please visit the vantage homepage for our latest articles or search our articles via the buttons below. Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment. 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Suzhou, Jiangsu Above is snippet of Google Trends for "Protein-Coupled Receptors" term, if you have problem loading the snippet, please visit here: Google Trend. In 2023, AllianThera Biopharma is currently focus on Protein-Coupled Receptors sector. Get involved to accelerate your cross-border partnering strategies. Sorry, we didn't find any related vantage articles. Aelix and Gilead, Immunocore and Corvus are all taking different approaches in the early hunt for a functional cure. In the recent past, Dr. Ding was Vice-President of Pfizer External Science & Innovation focusing on emerging sciences, promising products and innovative technologies in the Asia Pacific regions. AllianThera Biopharma was founded in China. The site is secure. Suzhou, Jiangsu Immunotherapy has shown limited efficacy in patients with EGFR-mutated lung cancer. PMID: 36066413 DOI: 10.1158/0008-5472.CAN-22-0770 Abstract Immunotherapy has shown limited efficacy in EGFR-mutated lung cancer patients. CD73 generates adenosine in MET-amplified EGFR-TKIresistant cells and is regulated by FRA1. Dr. Ding and Dr. Cote-Sierra, each has 20+ years of R&D experiences and leadership roles in major pharmas, were former colleagues at Pfizer. 2021325AllianThera Biopharma Insilico MedicineInsilico MedicinePandaOmics . They share a common passion in discovery and develop novel therapeutics for patients in need the most. 9 Guanghua Road, Chaoyang District, Beijing. MET-driven EGFR-TKI resistance is associated, MET-driven EGFR-TKI resistance is associated with induction of tumor cell STING. PEM treatment co-opts cGAS-STING signaling in MET-amplified EGFR-TKIresistant cells. Claim your Free Employer Profile. and transmitted securely. by contributing institutions or for the use of any information through the EurekAlert system. A, TCR expression, CD73 coactivation with STING in MET-driven EGFR-TKIresistant cells. Ai-biopharma - Ai powered drug discovery All fields are required. alicia@thrustsc.com. AllianThera Biopharma headquarter office and corporate office address is located in 4-B101-125, Creative Industry Park, No. Our Pharma.AI platform has the potential to rapidly bring novel breakthrough medicines to patients . 9 Guanghua Road, Chaoyang District, Beijing. 6005 Hidden Valley Road Suite 110 Carlsbad, CA 92011 858-293-4900. Bethesda, MD 20894, Web Policies Yamaoka T, Ohmori T, Ohba M, Arata S, Kishino Y, Murata Y, Kusumoto S, Ishida H, Shirai T, Hirose T, Ohnishi T, Sasaki Y. Mol Cancer Ther. Vaccines and neurology up for discussion, CROI 2023 GSK and Gileads long-acting HIV battle intensifies, CROI 2023 progress on efforts to cure HIV, Spotlight Cystic fibrosis developers take a deep breath, US deal watchdog's bark could be worse than its bite, Novo sows the seeds for a new heart failure approach. Stanford professor Michael Levitt, PhD, a member of Insilico Medicine's Scientific Advisory Board, won the Nobel Prize in Chemistry in 2013 for his groundbreaking work in protein structure and protein folding using computer modeling. Would you like email updates of new search results? AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of diseases, and Insilico Medicine, a global leader in deep learning for drug discovery and development, have announced a collaboration to discover and develop molecules for novel targets in cancer and autoimmune diseases. Impaired T-cell antigen-specific recognition of HCC827-GR6 cells despite elevated STING. We take on biologically-validated targets that have been previously elusive but that have the potential to transform medicine. ATB is a newly established biotechnology company led by seasoned drug hunters, Dr. Yuan-Hua Ding (CEO) and Dr. Javier Cote-Sierra (CSO), with seed money from Bohe Angel Fund, Anlong Venture and Kaitai Capital. The company's principal address is 11 Bantry Rd., Southborough . MET-driven EGFR-TKI resistance is associated with induction of tumor cell STING. 11 Allianthera Biopharma, Natick, MA, United States. A, Venn diagram showing the, CD73 is regulated by oncogenic MET in lung cancer cells. AllianThera Biopharma comes out of stealth and collaborates on AI with Insilico Medicine. GSK shows that Cabenuva every two months is as good as daily Biktarvy, but Gilead looks to go even longer. They share a common passion in discovery and develop novel therapeutics for patients in need the most. 328 Xinghu Street Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone Suzhou, Jiangsu China AllianThera Biopharma Timeline 2021 2022 Date Founded Financing Round Want detailed data on 3M+ companies? "Dr. Ding is one of the most respected biopharmaceutical executives in our industry focusing on novel drugs and technologies and we had the pleasure of working with him. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge and 1F C1, No. R01 CA190394/CA/NCI NIH HHS/United States, NCI CPTC Antibody Characterization Program, Kwon J, Bakhoum SF. General. Go to your account and send up to 300 emails per day using the Free plan. The https:// ensures that you are connecting to the This website expressly disclaims the accuracy, adequacy, or completeness of any data and shall not be liable for any errors, omissions or other defects in, delays or interruptions in such data, or for any actions taken in reliance thereon. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge and drug experiences with partners' technologies while leveraging unique strengths in different geographies, East or West. The lead product - Zorifertinib, with 100% BBB penetration, is the next-generation EGFR TKI drug especially designed for treatment in EGFR mutation positive advanced NSCLC patients with central nervous system metastases, which is the first-in-class drug and supported by national funds as National Major Project for New Drug Innovation of China. Here, we discover that MET amplification, the most common mechanism of resistance to third-generation EGFR tyrosine kinase inhibitors (TKI), activates tumor cell STING, an emerging determinant of cancer immunogenicity (1). Eccogene is a clinical stage biopharmaceutical company dedicated to providing innovative therapeutic solutions to address unmet medical needs globally. Shi P, Oh YT, Zhang G, Yao W, Yue P, Li Y, Kanteti R, Riehm J, Salgia R, Owonikoko TK, Ramalingam SS, Chen M, Sun SY. But is the agency really stopping deals from happening? -, Soria JC, Ohe Y, Vansteenkiste J, Reungwetwattana T, Chewaskulyong B, Lee KH, et al. Investors & Media. The next couple of years should show whether inhaled genetic projects have potential. Suzhou Industrial Park, Suzhou Area, China (Jiangsu) Pilot Free Trade Zone AllianThera Biopharma. SUZHOU, China, March 25, 2021 /PRNewswire/ --Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and developing innovative medicines for a broad range of diseases, and Insilico Medicine, a global leader in deep learning for drug discovery and development, announced a collaboration to discover and develop molecules for novel targets in cancer and autoimmune diseases. SUZHOU, China, March 25, 2021 /PRNewswire/ -- Today, AllianThera Biopharma (ATB), a Suzhou, China-based startup focusing on inventing and . China, developerGPCR-target drugbiological targetartificial intelligence technology(GPCR. About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease biology knowledge. AllianThera Biopharma Name: AllianThera Biopharma Industry: Pharma Location: Suzhou, Jiangsu, China Employees: 10-50 Description: About ATB (AllianThera Biopharma): Founded by a group of veteran pharma scientists, ATB strives to become a global leader in therapeutic innovation by combining our deep disease b. If this sounds like you, please get in touch with us. Industry Presence Many of the world's largest companies are operating and investing in our communities. Alpha Biopharma Specialize in drug innovation from clinical development to commercialization success. To connect with AllianThera Biopharma's employee register on Signalhire, Get the email address format for anyone with our FREE extension. 8600 Rockville Pike As a pharmaceutical company with global vision, supported by the domestic and foreign famous funds, Alpha Biopharma is committed to the clinical development of global innovative drug. Piper Companies is always on the lookout for new talent. Eccogene is specialized in disease biology, medicinal chemistry, and . Can your gut microbes tell you how old you really are? By using this site, you agree that we may store and access cookies on your device. Websitehttp://insilico.com/, Contact: Polly Firsanova (240) 641-6266 [emailprotected], Photo - https://mma.prnewswire.com/media/1473235/Insilico_AllianThera_Biopharma.jpg, https://mma.prnewswire.com/media/1473235/Insilico_AllianThera_Biopharma.jpg. It's caused by lack of insulin or insufficient insulin responses, leading to abnormal metabolism of sugar, protein and fat with imbalance of water and electrolytes. Copyright 20082023, Glassdoor, Inc. "Glassdoor" and logo are registered trademarks of Glassdoor, Inc. Find a Great First Job to Jumpstart Your Career, Learn How to State Your Case and Earn Your Raise, Work Here? Senior Scientist 5 jobs; AllianThera Biopharma Locations. See this image and copyright information in PMC. Since its inception, Insilico Medicine raised over $52 million, published over 100 peer-reviewed papers, applied for over 25 patents, and received multiple industry awards. Disclaimer: This website is not affiliated with AllianThera Biopharma, any government agency, does not create this data, vouch for its accuracy, or guarantee that it is the most recent data available. SUZHOU, China, March 25, 2021 /PRNewswire/ -- AllianThera Biopharma comes out of stealth and collaborates on AI with Insilico Medicine An official website of the United States government. -. Unauthorized use of these marks is strictly prohibited. For more than four decades, the SCT and its international membership have advocated for the use of clinical trials to inform science and advance human health and wellness. Delegates due to an error, unable to load your delegates due to an error is the really. Due to an error, unable to load your collection due to an,... 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